White matter lesions predict outcome in late depression

White matter lesions predict outcome in late depression

Cerebral organic changes, such as deep white matter lesions detected by magnetic resonance imaging, have been hypothesisedto be associated with depression in late life but their effecton the outcome of depression is unknown. O'Brien et al (p 982)followed 54 elderly people with major depression for three years.The presence of severe deep white matter lesions was significantlyassociated with a poor prognosis.

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Severe deep white matter lesions and outcome in elderly patients with major depressive disorder: follow up study: John O'Brien, David Ames, Edmond Chiu, Isaac Schweitzer, Patricia Desmond, and Brian Tress
BMJ 1998 317: 982-984. [Abstract] [Full Text] [PDF]