Inhalers are just as safe without chlorofluorocarbons

Inhalers are just as safe without chlorofluorocarbons

The need to monitor the safety of new medicines in large populations of patients is well established. Ayres et al (p 926)conducted a postmarketing surveillance study of the safety ofthe first licensed, pressurised metered dose inhaler to use anon-chlorofluorocarbon propellant $---$ the hydrofluoroalkane 134a salbutamolsulphate inhaler (Airomir, 3M) $---$ in primary care. They observedoutcomes in over 6000 patients who had been prescribed metereddoses of salbutamol delivered by inhalers using either hydrofluoroalkaneor chlorofluorocarbon as the propellant. Their findings supportedthe experience of clinical trials, showing that the reformulationdoes not result in significant changes in safety compared withmetered dose inhalers using non-chlorofluorocarbonpropellants.

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Relevant Article

Postmarketing surveillance study of a non-chlorofluorocarbon inhaler according to the safety assessment of marketed medicines guidelines: J G Ayres, C D Frost, W F Holmes, D R R Williams, and S M Ward
BMJ 1998 317: 926-930. [Abstract] [Full Text] [PDF]