Drug misuse and transfusion increase vertical transmission of hepatitis C
Studies of mother to infant transmission of hepatitis C virus have
shown a higher risk of transmission in women coinfected with HIV-1.
Resti et al (p 437) followed up the babies of a large population
(n=403) of pregnant women with antibodies to hepatitis C virus but not
HIV-1 for more than two years. They found that intravenous drug use
itself was an important risk factor for hepatitis C transmission to
infants, as was maternal post transfusional hepatitis. Viral genotype,
maternal viraemia, vaginal delivery, and breast feeding did not seem to
be risk factors for infant infection. Hepatitis C virus seems to be
transmitted in utero since viraemia was found in the first day of life.
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- Mother to child transmission of hepatitis C virus: prospective study of risk factors and timing of infection in children born to women seronegative for HIV-1
- Massimo Resti, Chiara Azzari, Francesco Mannelli, Maria Moriondo, Elio Novembre, Maurizio de Martino, Alberto Vierucci, and Tuscany Study Group on Hepatitis C Virus Infection in Children
BMJ 1998 317: 437-441.[Abstract] [Full Text] [PDF]
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