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Opinions are divided on whether research and
educational material funded by the tobacco, alcohol, or infant formula
industries can be scientifically sound or whether it is inevitably
tainted. Here, doctors, researchers, and a member of a pressure group
argue the pros and cons.
Christopher J Proctor British American Tobacco,
Millbank, Knowle Green, Staines, Middlesex TW18 1DY
Christopher_Proctor{at}britamtob.com
Smoking is strongly associated with several diseases,
sufficiently so for public health authorities to say that smoking is a
cause of disease and to have warned the public for many years of the
dangers of smoking. British American Tobacco respects these actions.
Yet science has still to ascertain precise biological mechanisms
whereby prolonged exposure to constituents of tobacco smoke causes
these diseases. Science has also yet to determine why, for most
diseases associated with smoking, the overwhelming majority of lifetime
smokers do not contract the diseases, and why there are geographical
differences in the incidence of many diseases that are related to
smoking.
The public health conclusion that smoking is a cause of disease can
lead to two quite different approaches. One approach determines that
nothing can be gained from a greater understanding of the relation
between smoking and disease, that no one should smoke, and that all
efforts should focus on persuading people not to smoke. The second
approach continues to persuade people not to smoke but accepts that
smoking is a popular custom and seeks to discover more about the
association between smoking and various diseases in order to determine
what changes to tobacco products might be introduced to reduce the
risks associated with smoking.
Historically, British governments have taken the second approach,
working with tobacco companies and supporting the funding of biomedical
research related to tobacco modification. This has led to a greater
understanding of smoking behaviour, constituents of smoke, and possible
mechanisms of disease. This knowledge has led to recommendations that
smokers should choose low tar cigarettes. The work of Britain's
Tobacco Products Research Trust is well documented as a sustained
effort to address smoking and health issues in a practical
manner.1
The question today is whether there is value in biomedical research
seeking to identify precisely the biological
mechanisms whereby long term exposure to constituents of tobacco smoke
may contribute to the development of disease. For British American
If it is agreed that such research is worth doing then the only
arguments against the tobacco industry contributing to the support of
such research would be either that the results of such research may be
presented in a skewed manner or that the results could in some way
confuse the public health message.
As far as the first point is concerned, fundamental biomedical research
has little value if the results are not peer reviewed and published for
general consideration. The second point requires a trust in the
integrity of scientific researchers and the peer review
process.2
Irrespective of the outcome of any particular scientific research, the
loss of mutual scientific respect between British American Tobacco and
public health authorities would be a disadvantage to the community;
surely collaboration, not confrontation, is the best approach to making
scientifically worthwhile progress on smoking and health.
References
Tom Sorell University of Essex, Wivenhow Park,
Colchester CO4 3SQ
tsorrell{at}essex.ac.uk
Perhaps the most straightforward objection to
sponsorship of medical research by tobacco companies is that as
soon as the source of the funding is known the research is discredited.
The tobacco industry has only itself to blame, for over the decades it
has put its own spin on damaging evidence. In the United
States especially, it has engaged scientists to publish papers
calling into question the many studies that have shown the
addictiveness of nicotine and the connection between heart and lung
disease and active and passive smoking. Rather like lawyers arguing a
case according to clients' instructions, the hired researchers have
often claimed that the apparently damaging evidence is not full enough
or have brought up arcane methodological objections. And the
partisanship of some of these papers has often been concealed. The
links of the authors with the tobacco industry have been covered up.
Raising questions not answering them
Payments to some tobacco researchers have come from secret funds
or front organisations with misleading names. Much worse, the industry
has suppressed findings of its own researchers that bear out what its
opponents have claimed. In short, a programme of scientific publication
has been developed to raise questions rather than answer them. And the
choice of questions to be raised has been determined not by unexpected
or unexplained data, but by judgments about the pieces of scientific
research and the claims of researchers that pose the greatest obstacle
to marketing cigarettes.
The strategy of trying to discredit evidence of a health risk from
smoking has been followed not only in the United States and not only by
American tobacco companies. In June 1996, Philip Morris produced a
press pack suggesting that both science and public opinion went against
proposals for sweeping smoking bans in Europe. The "science" was
produced by the European Working Group on Environmental Tobacco Smoke
and Lung Cancer, a group financed by the tobacco industry. The group's
findings have been challenged by epidemiologists at Bristol University
and the Royal Free Hospital School of Medicine. A Dutch professor, P H
M Lohman, who had contributed to the report of the working group,
disavowed it when Philip Morris advertisements compared the risks of
passive smoking to those of eating biscuits or drinking water. Since
1994, a Swedish tobacco company, Svenska Tobaks, has been one of the
sponsors of the Centre for Indoor Air Research. In Finland Professor
Ismo Virtanen has been involved in legal disputes over whether evidence
he presented on behalf of two tobacco companies in a suit against them
was distorted by undisclosed payments from tobacco companies. As
recently as February of this year, tobacco manufacturers in Germany
contested requirements to advertise not only a general health warning
but risks of cancer and heart disease from smoking. The manufacturers
claimed that their "freedom of opinion" was imperilled by the
health warnings. In Britain, according to the Lancet,
the numbers of industry funded papers peaked in 1991. One of the bodies
channelling the funds from tobacco companies was called the Health
Promotion Research Trust.
The tobacco industry also sponsors non-medical research and
non-medical academic posts. When it is open about such sponsorship, how
strong is the moral case against it? In July 1996, academics at
Cambridge voted to accept £1.5m from BAT Industries to establish the
Patrick Sheehy chair in international relations, named after the
tobacco company's chairman. Academics opposing the acceptance of this
donation called it "blood money," on the grounds that it was
proceeds from the sale of a lethal product. But it is far less
objectionable than medical sponsorship, as appointments to the chair
are in the hands of a university in which there is a lot of criticism
of the tobacco industry and in which the post could not easily be
turned into a source of tobacco promotion. Indeed, in the light of the
controversy over accepting the sponsorship, holders of the chair might
feel that they had to prove their independence from the sponsors. A
troubling intermediate case is the sponsorship by BAT of research into
leisure. Like the direct sponsorship of leisure and sport by tobacco
companies, the funding of leisure research seems calculated to
associate smoking with an area of life
Hurst Hannum Fletcher School of Law and
Diplomacy, Tufts University, Medford, MA 02155, USA
hhannum{at}tufts.edu
Almost all funding comes with strings attached. At a
minimum, the recipient must be accountable for how grants are spent. At
a maximum, the recipient must deliver a particular product that is
acceptable to the donor. Whether funds are received from the
researcher's university, the government, an intergovernmental
organisation, industry, or a private donor, the research that is
carried out must be of a professional standard and The argument has been advanced that funding from the drinks industry is
somehow so tainted that it corrupts any research endeavour and should
be rejected. It is difficult to understand, however, why money from the
drinks industry is any more corrupting than money from the
pharmaceutical, food, car, or chemical industries, each of which also
has profitmaking as its primary corporate goal. And, if the profit
motive can bias research then certainly the possible ideological bias
of governments There seem to be two primary arguments against industry funding of
alcohol research: (a) that researchers who receive such
funding engage in poor biased science, which can mislead the public and
policymakers; and (b) that industry funding
improperly distorts the scientific research agenda, to the detriment of
public health.
The first objection, if true, should be met by applying the same
professional standards applicable to any research, whatever the source
of funding. Whether the results are published in peer-reviewed journals
or by advocacy organisations, the quality of scientific research should
be judged on its own merits. Sloppy or slanted research should be
rejected, and it is doubtful whether the personal reputation of any
researcher could survive well founded allegations of bias.
The second objection seems to be based on an exaggerated premise, since
research funded by the drinks industry pales beside that supported
either by other industries, such as the pharmaceutical industry, or
national governments. For example, the Alcohol Beverage Medical
Research Foundation (the major industry funder of scientific research
in the United States) contributed about $2m (£1.3m) to alcohol
research in 1995; and the National Institute on Alcohol Abuse and
Alcoholism (funded by the US government) spent nearly $200m in 1996, most of which was devoted to research. In any case, the logical
response to inappropriate research (research that answers questions the
critics would rather not have asked) or inadequate research is to
increase funding from other sources, not to diminish the total pool of
available knowledge.
None the less, the suspicion remains that the source of money may call
into question the integrity of the recipient, whether it is industry
funding of alcohol research or government funding of human rights
organisations. This suspicion is deepened if an organisation tries to
conceal the source of funding or when an individual or organisation
comes to rely too heavily on a single, interested source. It is also
true that some companies and other interested parties do attempt to
manipulate scientific research and mislead the public.
The response to these concerns should not be to prohibit research
that is needed but rather to develop ethical principles to protect the
integrity of donors and recipients. To this end, a meeting of 24 experts The Dublin Principles call on industry, governments, and
non-governmental organisations to support independent scientific
research on "the use, misuse, effects, and properties of alcohol and
the relationships among alcohol, health, and society." They mandate
full disclosure of funding sources and of any potential conflicts of
interest when seeking funding, and they set forth the basic principle
that researchers should be free to disseminate and publish the results
of their work. The effect of these principles will depend on their
acceptance by industry and researchers and, ultimately, on a mechanism
to monitor compliance with their provisions.
A blanket prohibition of industry funding may be simpler than directly
addressing the ethical issues surrounding the relationship between
funder and recipient. We should also respect the beliefs of those who
argue against drinking on moral or religious grounds. However, a
condemnation of the drinks industry and thereby elimination of
potentially useful research because of moralistic ideology should be
rejected by anyone who claims to serve the interests of science.
Acknowledgments
Conflict of interest: HH worked as a part time consultant to
the International Center for Alcohol Policies
Griffith Edwards National Addiction Centre,
London SE5 8AF
spjepad{at}iop.bpmf.ac.uk
Should researchers take money from the drinks industry?
Alcohol always excites passion. I will try to identify some of the
issues that may properly bear on deciding how to answer that question.
It is useful to distinguish between the inherent ethicality of a
product and that of the industry which manufactures and markets that
product. Alcohol is in ethical terms an unusually ambiguous commodity.
It provides employment, gives pleasure, can be consumed without harm,
and may even perhaps confer health benefit. But it is also a toxic and
addictive substance that causes illness, accident, violence, death,
family suffering, and social costs Alcohol is not as dirty a product as tobacco, but if we choose to take
money from the drinks industry we should be willing to admit that the
money stems from profits derived not only from the marketing of fun but
also from the sale of morbidity and mortality. Hence the ambiguity. And
yet are we not indirectly taking drinks and tobacco money all the time,
with the chancellor our collecting agent?
And what of the people who work in the drinks industry? Are they the
sort of individuals with whom researchers should be willing to sip and
sup? If we take the industry's money we inevitably confer on those
individuals a little bit of respectability. Some of us who have had
recent experience of the industry's machinations are likely to contend
that it has, over the past few years, too often behaved as if it were
on a convergent path with the worst practices of the tobacco industry.
The drinks conglomerates are very clearly targeting young people, as
witnessed by their woeful behaviour over "alcopops." They are
trying to target the developing world in a way highly reminiscent of
the tobacco manufacturers.1 They are denying the relevance
of scientific evidence of population consumption for public health in a
manner strikingly reminiscent of the feigned blindness of the tobacco
industry to the addictiveness of nicotine. They have set up front
organisations, such as the Washington based International Center for
Alcohol Policies, the Amsterdam Group, and the Portman Group, which are
willing to clone the tobacco industry tactics.
Amusingly, the Portman Group is to be found in the 1995 telephone
directory under its true colours as "research and media releases for
the drinks industry," but it has since put on a new disguise and
re-emerged as "the industry's watch dog." And it was of course the
Portman Group that in 1994 sought to pay academics £2000 each for
joining an anonymous attack on a report by the World Health
Organisation2 that had documented evidence on the relation
between alcohol consumption and drinking problems.3
So should researchers take research money from a tainted industry which
exploits vulnerable populations, mounts attacks on valid research and
independent researchers, and which, through its front organisations,
tries to distort the truth? Those considerations suggest perhaps an
answer tilting towards a "no" in a more obvious way than some
scientists might on first inspection have thought.
Here, however, are some linked proposals for an interim solution to the
dilemma. Firstly, it could be agreed that no one should accept money
direct from the drinks industry. Direct funding of that kind is seldom
adequately refereed and is often aimed at biasing activity in the
field.4 Secondly, funding at arm's length through an
intermediary organisation might be seen as acceptable, provided that
the intermediary is genuinely free from direct or indirect influence
from the drinks industry. Thirdly, the industry should be invited to
dismantle its front organisations before they are forced in that
direction, as happened in a recent court agreement in the United States
with the tobacco industry.
Any middle way can indeed only be provisional. If the drinks industry
goes on behaving in Britain and in other countries in its present
unethical manner, it will inevitably and deservedly join the tobacco
industry in a pariah status.
References
Alan Lucas MRC Childhood Nutrition Research
Centre, Institute of Child Health, London WC1N 1EH
Companies have in the past received intense criticism over
the marketing of infant formula in developing countries, where
reduction in breast feeding has been associated with morbidity and
shorter intervals between births. Despite official intervention,
international codes of practice, national legislation, and a code drawn
up by the manufacturers of infant formula, political debate continues.
An investigation last year of infringements of the World Health
Organisation's code in five countries1 Sponsorship remains an emotive issue. Some contend that it is wholly
improper for clinical research, scientific meetings, or professional
organisations to be financially assisted by formula companies.
Conversely, the editor of an international paediatric journal,
supporting sponsorship, stated: "It is quite extraordinary how in
such a serious debate over the years, these aggressive attacks [on the
infant formula industry] have been led by groups with scanty
scientific-epidemiological evidence, together with a most unwelcome
emotional component."3 As director of a politically
"neutral" government-funded (MRC) Childhood Nutrition Centre, I
shall attempt to steer among these polarised views.
The importance of infant formula and of manufacturers of infant
formula, at least in the West, deserves emphasis. Regular cows' milk
is not now recommended for babies aged under 12 months, so unless all
mothers were persuaded to breast feed for a year regardless of personal
circumstances, we need infant formula. We also need it in cases of
lactational failure and maternal death (0.5 million cases a year
worldwide) and when breast milk endangers the infant Furthermore, although formula manufacturers cannot by law advertise to
mothers, of the 750 000 women who become pregnant annually in Britain,
350 000 approach the industry directly for advice. Indeed, since
paediatric nutrition has no formal subspecialty status and little
specialist medical training exists, the infant formula industry is an
important information source for parents. In 1997 a leading baby milk
manufacturer distributed 300 000 articles to British parents in
support of breast feeding.
The low prevalence of breast feeding causes concern, and some find the
industrial input to maternal education upsetting. But in reality,
manufacturers of infant formula have a major role in the health care of
infants.
As infant formula is the commonest food used for Western infants,
research into its efficacy and safety is essential. Evidence that
nutrition during critical, early stages may have important programming
effects on adult health
5 6
puts a new onus on formula
manufacturers to carry out high quality outcome studies. The design of
the formula can have significant effects in premature babies on
cognitive, immunological, and bone outcomes years
later.
5 7 8
Interestingly, in baboons, breast feeding
followed by an "unphysiological" Western-style diet (as, arguably,
occurs in humans) resulted in more atherosclerosis in adulthood than in
those fed formula9; and in humans, males who were breast
fed beyond a year were at increased risk of cardiovascular
disease.10 Although these preliminary observations should
not influence practice, they signal that even the most cherished views
should not be immune to future critical research.
Research into infant nutrition is fast moving, requiring substantial
investment and close collaboration between responsible clinical
scientists and industry. Manufacturers cannot and should not operate
independently. The WHO recognises the need for quality feeding products
for infants, implying a research need. Provided that researchers
declare their funding sources, they should not be censored for
industrial collaborative research into child health. Indeed,
influential findings on the importance of breast milk come from
industrially supported studies.
11 12
Educational sponsorship is contested. One breast feeding organisation
contends that a medical conference is not "baby friendly" if the
baby food industry acts as a sponsor or has a commercial presence Sponsorship of major professional organisations, however, is more
problematic. Whereas some wish to see these independent of any
commercial input, others argue that we should encourage the infant
formula industry and the medical profession to work together by
allowing the industry to be part of the scientific community.
The real conflict is that some still contend that manufacturers of
infant formula damagingly compete with breast feeding worldwide and
that company affiliations affect the independence of health
professionals. The counter view is that formula manufacturers now in
general act responsibly, within local laws, and References
Patti Rundall Baby Milk Action, 23 St Andrew's
Street, Cambridge CB2 3AX
babymilkacti{at}gn.apc.org
Sponsorship is "a payment by a business firm
... for the purpose of promoting its name, products
or services. It is a commercial deal, not a philanthropic gift." This
is how the British government described sponsorship in a 1986 leaflet
issued by the Office of Arts and Libraries.
Sponsorship is vital to a company's marketing strategies, and it
affects not only our health, and our environment but also whether
people live or die. Because so many influential health professional
bodies and doctors in industrialised countries have given up the fight
for adequate public funding of essential research, training, and
information Some scientists argue that it is a public health duty to work with
companies to improve the quality of products. They are affronted by any
suggestion that such involvement might constitute a conflict of
interest. In the case of infant feeding, however, the nutritional
advantages of one brand of artificial formula over another and the
development of niche products such as specialised formulas Is it reasonable to believe that development of formulas is driven by
concern for health? If it is, why do leading companies allow the
composition of their brands to vary from country to country? Why are
expensive ingredients added only if accompanied by health claims, which
will result in increased sales? Why do infant formulas contain cheap
ingredients, such as sucrose, when sold in Asia, but not when sold in
Europe? Can it be ethical that better quality formulas are the
prerogative of rich populations? And when problems of contamination
arise, why do companies have to be forced to reveal the extent of the
problem?
How is it that scientists, who pride themselves on their academic
rigour in the laboratory, so often seem to be unaware of these issues?
Why do so many fail to monitor the activities of their sponsors or
acknowledge the impact that their involvement might have in the global
context? Why are the bland corporate assurances that these products
will answer world hunger, or that they adhere to UN resolutions,
believed by so many? Why is it only the non-profit, non-governmental
organisations that publicise and expose marketing activities and call
for stricter controls?
Companies Of course they have a responsibility to research and improve products,
and of necessity they must employ scientists. But such involvement
inevitably creates a conflict of interest, and this is why corporations
go to such lengths to ensure that their scientists sit on influential
committees such as the Committee on Medical Aspects of Food, Codex
Alimentarius Commission (the commission that produces recommended food
standards for the world), the new Food Standards Agency, or the
European Scientific Committee for Food. Some of these committees have
already had an important influence on food laws and the public and are
part of the reason that UK law is so weak and that so few women in
Britain breast feed. Surely the public should be able to trust that
such public bodies do not favour commercial interests over public
health.
As long ago as 1983, Professor John Reid of the University of Cape Town
said to industry representatives at the 12th annual meeting of the
World Sugar Research Organisation: "There is a hidden agenda in the
research support business. Those who accept your [industries']
support are often perceived to be less likely to give you a bad
scientific press. They may come up with the results that cause you
problems, but they will put them in a context in a way that leaves you
happier than had they emanated from someone not receiving your support.
My own observation and comment is that this hidden effect is powerful,
more powerful certainly than we care to state loudly, from the point of
view of honour either in science or in industry. It takes a lot to bite
the hand that feeds you."
The world is facing many difficult problems that need the close
attention of everyone concerned with public health. If sustainable
solutions are to be found, surely it is imperative that adequate public
funds are set aside for this purpose References
Tobacco, such an effort is clearly worth while as such investigations
may lead to support from public health authorities for product
modifications. For biomedical researchers, we also think that there is
value as such efforts should lead to a greater understanding of disease
and hence to the reduction of disease incidence and improvements in
treatment.
Tobacco company sponsorship discredits medical but
not all research
active leisure
pursuits
in which smoking may be made to seem (incorrectly) to
be a harmless occasional indulgence rather than a health hazard.
Condemning the drinks industry rules out
potentially useful research
particularly if
additional funding will be sought in the future
should be relevant to
the concerns of the funder or science generally.
for example, alcohol or high energy consumption is in
itself undesirable
must be equally suspect.
including scientists, industry executives, government
officials, public health experts, and individuals from
intergovernmental and non-governmental organisations
adopted a set of
"Principles of Cooperation among the Beverage Alcohol Industry,
Governments, Scientific Researchers, and the Public Health Community"
in Dublin in May 1997. These "Dublin Principles" recognise the
social responsibility of the private sector, as well as of researchers,
"to further public knowledge about alcohol and prevent its misuse."
This responsibility includes the presentation of information to the
public on the health and societal impact of alcohol in an "accurate
and balanced manner."

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Funding from the drinks industry stems from profits derived from
the sale of morbidity and mortality
a non-profit
organisation based in Washington, DC, and funded by 11 major
international drinks companies
developing early drafts of the Dublin
Principles. Many years ago he wrote four books and numerous articles on
wines and spirits, none of which was supported by the drinks industry.
If the drinks industry does not clean up its act,
pariah status is inevitable
on a vast scale. And despite the
disingenuous attempts of the drinks industry to uncouple "use" from
"misuse" there is compelling research evidence showing that the
greater the population's per capita consumption of alcohol, the
greater the related harm will be. Alcohol use has a lot to do with the
burden of alcohol problems.
Collaborative research with infant formula
companies should not always be censored
although
criticised for flawed science2
has further fanned the
flames.
for example, if
the mother has HIV infection or is taking certain drugs or if the
infant has certain rare inborn errors of metabolism. In premature
babies, human milk requires supplementation with formula products to
meet the infants' special needs and prevent substantial
undernutrition. Even in developing countries, infant formula is safer
than alternatives when breast feeding is impossible or
inadvisable
though risks of introducing formulas into such
environments are well recognised. In the United Kingdom in 1995 the
prevalence of breast feeding at 4 months was only 27%,4
so most babies will need formula milk for most of infancy, even those
initially breast fed.

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Research into the efficacy and safety of infant formula is
essential
for
example, through stalls, advertising, etc. Educational achievements of
the industry have, however, been impressive. Over 100 Ross conferences
in the United States, about 50 Nestlé workshops, and major inputs
from other infant formula manufacturers have produced prominent
publications, objective discussion, and policymaking over wide ranging
issues, including breast feeding
with undoubted contribution to health
care.
unlike, say, tobacco
companies
answer a clinical need. The issues require sensitive
consideration. Nevertheless it is my observation that most clinicians,
including me, believe that formula companies provide a critical
contribution to infant health care, health education, and high quality
research.
How much research in infant feeding comes from
unethical marketing?
and have become dependent on corporate finance
those who
should be speaking out on behalf of public health are often silent when
debates arise about legislation to control corporate sponsors and stop
commercial exploitation.
the focus
of so much research
have far less impact on world health compared with
the enormous benefits derived by infants if they have access to their
mothers' milk. This is especially true when mothers cannot read or
have no access to sanitation or money to buy sufficient quantities
of the product. Yet much of the money that funds research in infant
feeding is profit from the unethical marketing of breast milk
substitutes to the world's poorer populations.1-3
especially those that are the subject of criticism
have a
particular need to offer sponsorship, knowing that it works on many
levels. Without it, they would find it much harder to silence potential
critics; create the image that they are responsible "corporate
citizens" who can be trusted to regulate themselves; influence public
health policies and priorities; link their name to prestigious
non-governmental organisations, United Nations agencies, and doctors;
affect the direction and outcome of research; create dependency; create
public confusion about the real causes of poverty.
instead of money that has already
been allocated by industry for an entirely different purpose, namely
marketing.
pushing commercial infant foods in Pakistan.
Islamabad: Network for the Rational Use of Medication
, 1998(Available from Baby Milk Action.)
© BMJ 1998
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