Excess risk of death with selegiline is small

Excess risk of death with selegiline is small

Concern has been raised about the possibility that use of selegiline in combination with levodopa to treat patients with Parkinson'sdisease is associated with an increased risk of death. Thorogoodet al examined data on patients taking drugs for Parkinson's diseasewho are included in the General Practice Research Database (p 252).They found a small, non-significant increase in risk of deathin patients taking selegiline in combination with levodopa anda slightly greater, but still non-significant, increase in riskof death in patients taking selegiline alone. They conclude thatexcess risk associated with use of selegiline would be small.

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Mortality in people taking selegiline: observational study: Margaret Thorogood, Ben Armstrong, Tom Nichols, and Jen Hollowell
BMJ 1998 317: 252-254. [Abstract] [Full Text] [PDF]