Fetal growth rate affects risk of ischaemic heart disease

Controversy still surrounds the hypothesis that circumstances in utero can affect the risk of cardiovascular disease in adult life. On page 241 Leon et al present the results of a large Swedish cohort study that avoids the shortcomings of previous studies. They show that among men the risk of death from ischaemic heart disease declines as birth weight increases. It is fetal growth rate rather than size at birth that is the important determinant of risk. How far maternal nutritional status underlies this is unclear.


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