Long term hormone replacement therapy is needed to prevent hip fractures

Long term hormone replacement therapy is needed to prevent hip fractures

Unresolved issues concerning the protective effect of postmenopausal hormone replacement therapy on the risk of hip fractureinclude the effect of duration of and time since last treatment,the addition of progestin, route of administration, and dose.On p 1858 Michaëlsson et al present data from a Swedish populationbased case-control study with 1327 hip fracture cases and 3262controls. The results indicate that recent use of hormone replacementtherapy is required for optimum fracture protection; after fiveyears without therapy the protective effect was substantiallydiminished. Hormone replacement therapy could be started severalyears after the menopause, and the protective effect increaseswith duration of use. Lower doses of oestrogen are required forprotection when progestins are included in the regimen. Efficacy seems unrelated to route of administration.

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Hormone replacement therapy and risk of hip fracture: population based case-control study: Karl Michaëlsson, John A Baron, Bahman Y Farahmand, Olof Johnell, Cecilia Magnusson, Per-Gunnar Persson, Ingemar Persson, and Sverker Ljunghall
BMJ 1998 316: 1858-1863. [Abstract] [Full Text] [PDF]