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Depression is an independent risk factor for increased morbidity and
mortality after a myocardial infarction. In a case-control study in
primary care, Hippisley-Cox et al (p 1714) investigated whether
depression occurs before the onset of ischaemic heart disease. They
found that men who were depressed were three times more likely than
controls to develop ischaemic heart disease. This association was
independent of smoking status, diabetes, hypertension, and deprivation
score. A similar risk was not found in women.