Colloids no better than crystalloids for fluid replacement in hypovolaemic patients

Colloids no better than crystalloids for fluid replacement in hypovolaemic patients

For decades controversy has existed over the relative benefits of colloid and crystalloid solutions for fluid resuscitationof hypovolaemic patients. In their systematic review of randomisedcontrolled trials Schierhout and Roberts (p 961) found that, comparedwith crystalloids, use of colloids was associated with an increasein absolute risk of mortality of 4%. There was no evidence fordifferences of effect among different types of injury necessitatingfluid resuscitation. The authors conclude that there is no evidenceto support the continued use of the more expensive colloids foracute volume replacement in critically ill patients.

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Fluid resuscitation with colloid or crystalloid solutions in critically ill patients: a systematic review of randomised trials: Gill Schierhout and Ian Roberts
BMJ 1998 316: 961-964. [Abstract] [Full Text] [PDF]