Folic acid and vitamin B-12 and B-6 supplements reduce blood homocysteine concentrations
Higher blood concentrations of homocysteine seem to be associated with
higher risks of occlusive vascular disease, and are inversely related
to blood concentrations of folate and vitamins B-12 and B-6. The
Homocysteine Lowering Trialists' Collaboration (p 894) reviewed data
for 1114 subjects in 12 randomised trials of folic acid based
supplements to assess the effects on blood homocysteine concentrations
of different doses of folic acid, with or without vitamins B-12 and
B-6, and found that reductions in blood homocysteine with folic acid
supplementation were greater at higher pretreatment concentrations of
blood homocysteine and at lower pretreatment concentrations of blood
folate. Vitamin B-12 produced additional reductions. In typical Western
populations, daily supplementation with both 0.5-5 mg folic
acid and about 0.5 mg vitamin B-12 would be expected to reduce blood
homocysteine concentrations by about a quarter to a third.
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- Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials
- Homocysteine Lowering Trialists' Collaboration
BMJ 1998 316: 894-898.[Abstract] [Full Text] [PDF]
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