Some infants develop hypoxaemia when breathing 15% oxygen

Some infants develop hypoxaemia when breathing 15% oxygen

Some infants may develop hypoxaemia in air with oxygen reduced to 15% $---$ similar to that found in aircraft and at high altitude.To investigate the effects of 15% oxygen on the control of breathingParkins et al (p 887) exposed 34 infants to 15% oxygen. Bloodoxygen saturation was maintained at slightly reduced values inmost infants but in four infants values fell greatly. This adverseresponse could not be predicted from measurements made in roomair before exposure to 15% oxygen. These findings may explainwhy some infants with reduced oxygen in their airways as a resultof respiratory infection develop sudden or persistent falls inblood oxygen saturation.

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Effect of exposure to 15% oxygen on breathing patterns and oxygen saturation in infants: interventional study • Commentary: Safety of participants in non-therapeutic research must be ensured • Commentary: Ethical approval of study was warranted • Authors' reply: K J Parkins, C F Poets, L M O'Brien, V A Stebbens, D P Southall, Julian Savulescu, Vivian Hughes, K J Parkins, C F Poets, L M O'Brien, V A Stebbens, and D P Southall
BMJ 1998 316: 887-894. [Abstract] [Full Text] [PDF]