Calcium channel blockers may increase risk of suicide
A recent study suggested an excess risk of depression with calcium
channel blockers. Lindberg et al (p 741) therefore investigated the
risk of suicide associated with cardiovascular drugs, with special
reference to calcium channel blockers. In a cross sectional ecological
study of 152 Swedish municipalities they found a significant correlation between the use of calcium channel blockers and the incidence of suicide. In a population based cohort study of subjects who purchased various antihypertensive drugs in 1988-9 they then found
a fivefold increase in the incidence of suicide in users of calcium
channel blockers compared with non-users during follow up until the end
of 1994.
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- Use of calcium channel blockers and risk of suicide: ecological findings confirmed in population based cohort study
- Gunnar Lindberg, Kerstin Bingefors, Jonas Ranstam, Lennart Råstam, and Arne Melander
BMJ 1998 316: 741-745.[Abstract] [Full Text] [PDF]
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