Polymerase chain reaction is useful in defining infectiousness of people with hepatitis C
The ability to determine infectiousness among people with hepatitis C would help in counselling those exposed to infection about the risk of transmission. As many people with antibodies to hepatitis C do not develop chronic infection, the polymerase chain reaction is required to detect ongoing viraemia. On p 333 Dore et al analyse published studies of hepatitis C transmission, covering 2022 people exposed to sources positive for antibody to hepatitis C. No transmissions occurred from people positive for hepatitis C antibody but with negative results by polymerase chain reaction.
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