Low dose aspirin with heparin improves prognosis in women with recurrent miscarriages

Recurrent miscarriage may represent a defective haemostatic response to pregnancy. Women with phospholipid antibodies, lupus anticoagulant, and cardiolipin antibodies have a miscarriage rate of 90%, attributed to placental thrombosis, in pregnancies in which no pharmacological treatment is given. On p 253 Rai et al report a randomised controlled trial of low dose aspirin and combined low dose aspirin and heparin in women with recurrent miscarriages and phospholipid antibodies. In women given aspirin alone the rate of live births was 40% but in those given aspirin and heparin it was 70%. The long term use of low dose heparin resulted in few side effects.


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