Published 23 October 2009, doi:10.1136/bmj.b4370
Cite this as: BMJ 2009;339:b4370

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Full data from Thai HIV vaccine study show no significant protective effect

Bob Roehr

1 Washington, DC

The first 150 words of the full text of this article appear below.

Disclosure of the full data from the trial of an HIV vaccine in Thailand shows that although there was a trend towards the prevention of HIV among vaccine recipients this did not reach statistical significance.

The study sparked controversy in September when the authors released incomplete trial results, in which one type of analysis showed the vaccine reduced infection rate by a third (BMJ 2009;339:b3963, doi:10.1136/bmj.b3963). Critics said that they should have waited until complete data were available for release.

The additional data were presented at the AIDS Vaccine 2009 conference in Paris on 20 October and simultaneously published in the New England Journal of Medicine (2009 Oct 20, doi:10.1056/NEJMoa0908492).

The study involved 16 402 participants aged 18 to 30, who were broadly representative of the local population. They were randomised to receive a series of six shots of either placebo or two different vaccines . . . [Full text of this article]


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HIV vaccine reduces infection rate by a third, study shows
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BMJ 2009 339: b3963. [Extract] [Full Text]

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