Reactive hypoglycaemia in severe mental illness

doi:10.1136/bmj.b2536

Published 23 June 2009, doi:10.1136/bmj.b2536
Cite this as: BMJ 2009;338:b2536

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Drug hypoglycaemia

Reactive hypoglycaemia in severe mental illness

The first 150 words of the full text of this article appear below.

Suzuki and colleagues describe hypoglycaemia induced by secondgeneration antipsychotic agents in schizophrenic non-diabeticpatients.¹

Since 2003 we have tested all patients treated with antipsychoticdrugs at the university psychiatric centre in Belgium usinga standard protocol including an oral glucose tolerance test.²From November 2003 to July 2007, 2223 tests were conducted in707 non-diabetic patients with severe mental illness screenedfor metabolic disturbances; 503 were diagnosed with schizophrenia,92 with schizoaffective disorder, and 112 with bipolar disorder.³Of the 2223 tests, 19.2% yielded a glucose concentration at120 minutes of <3.9 mmol/l; 10.6% were between 3.9 and 3.3mmol/l, 5.9% between 3.3 and 2.8 mmol/l, and 2.7% <2.8 mmol/l.

Multilevel regression of hypoglycaemia at 120 minutes usingthree stage cut-off points (0, >3.9 mmol/l; 1, <3.9 and>3.3 mmol/; 2, <3.3 and >2.8 mmol/l; 3, <2.8 mmol/l),found that increased risk was not associated with insulin resistance,antipsychotic . . . [Full text of this article]

Ruud van Winkel, psychiatrist and assistant professor¹, Marc De Hert²

¹ Maastricht University Medical Centre, PO Box 616, 6200 MD Maastricht, Netherlands, ² University Psychiatric Centre, Catholic University Leuven, Leuvensesteenweg 517, 3070 Kortenberg, Belgium

ruud.vanwinkel@sp.unimaas.nl

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Hypoglycaemia induced by second generation antipsychotic agents in schizophrenic non-diabetic patients: Yutaro Suzuki, Junzo Watanabe, Naoki Fukui, Vural Ozdemir, and Toshiyuki Someya
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