Published 4 June 2009, doi:10.1136/bmj.b2236
Cite this as: BMJ 2009;338:b2236
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Study questions benefits of immediate hormone therapy after menopause
Roger Dobson
1 Abergavenny
| The first 150 words of the full text of this article appear below. |
No evidence shows that hormone therapy started soon after menopause has a beneficial effect, according to a study in the American Journal of Epidemiology (2009 May 25, doi:10.1093/aje/kwp115). The authors found no support for the postmenopausal oestrogen timing hypothesis—that is, that treatment initiated soon after menopause prevents coronary heart disease and that treatment started later has a null or adverse effect.
The US authors further analysed results from the Women’s Health Initiative randomised controlled trials of 0.625 mg/day of conjugated equine oestrogens (CEE) among 10 739 women after hysterectomy and conjugated equine oestrogens plus 2.5 mg/day of medroxyprogesterone acetate (MPA) among 16 608 women with an intact uterus. The trials were designed to look at the effects of hormone treatment on risk of heart disease and overall health benefits and risks.
The trial was stopped early in 2002 after an average of 5.6 years of follow-up, on the
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