Atosiban v nifedipine

doi:10.1136/bmj.b1501

Published 14 April 2009, doi:10.1136/bmj.b1501
Cite this as: BMJ 2009;338:b1501

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Adverse reactions to tocolytics

Atosiban v nifedipine

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De Heus and colleagues conclude that oxytocin antagonists andcalcium channel blockers should be compared for tocolytic efficiencyand side effects.¹

Two (small) randomised controlled trials comparing atosibanand nifedipine have been published.² ³ Pooling their data ontocolysis before 35 weeks’ gestation yields 71 women givenatosiban and 72 nifedipine, delivery being postponed in 57 and56 respectively (P=0.713, odds ratio 1.08, 95% confidence interval0.71 to 1.65). Side effects such as arterial hypotension occurredin 1 woman given atosiban and 25 given nifedipine (P<0.001,odds ratio 16.7, 2.43 to 115.9).

Cite this as: BMJ 2009;338:b1501

Yves Jacquemyn, head¹

¹ Department of Obstetrics and Gynaecology, Antwerp University Hospital, Wilrijkstraat 10, 2650 Edegem, Belgium

yves.jacquemyn@uza.be

Competing interests: None declared.

De Heus R, Mol BW, Erwich JJ, van Geijn HP, Gyselaers WJ, Hanssens M, et al. Adverse drug reactions to tocolytic treatment for preterm labour: prospective cohort study. BMJ 2009;338:b744. (5 March.)[Abstract/Free Full Text]
Kashanian M, Aklbarian AR, Soltanzadeh M. Atosiban and nifedipine for the treatment of preterm labor. Int J Gynecol Obstet 2005;91:10-4.[CrossRef][Medline]
Al-Omari WR, Al-Shammaa HB, Al-Tikriti EM, Ahmed KW. Atosiban and nifedipine in acute tocolysis: a comparative study. Eur J Obstet Gynecol Reprod Biol 2006;128:129-34.[CrossRef][Web of Science][Medline]

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Adverse drug reactions to tocolytic treatment for preterm labour: prospective cohort study: Roel de Heus, Ben Willem Mol, Jan-Jaap H M Erwich, Herman P van Geijn, Wilfried J Gyselaers, Myriam Hanssens, Linda Härmark, Caroline D van Holsbeke, Johannes J Duvekot, Fred F A M Schobben, Hans Wolf, and Gerard H A Visser
BMJ 2009 338: b744. [Abstract] [Full Text] [PDF]