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Published 29 September 2008, doi:10.1136/bmj.a1530
Cite this as: BMJ 2008;337:a1530
Emily Crowe, research fellow1, David Halpin, consultant physician & honorary senior clinical lecturer2, Paul Stevens, consultant nephrologist3, on behalf of the Guideline Development Group
1 National Collaborating Centre for Chronic Conditions, Royal College of Physicians, London , 2 Royal Devon & Exeter Hospital, Exeter, 3 Kent and Canterbury Hospital, Canterbury CT1 3NG
Correspondence to: P Stevens paul.stevens@ekht.nhs.uk
| The first 150 words of the full text of this article appear below. |
Chronic kidney disease is associated with substantial comorbidity including hypertension, cardiovascular disease, anaemia, and renal bone disease. People with chronic kidney disease have a far greater likelihood of cardiovascular death than progression to established renal failure (requiring dialysis or kidney transplantation).1 2 3 4 Chronic kidney disease has been highlighted as a public health problem through the international adoption of the US National Kidney Foundations Kidney Disease Outcomes Quality Initiative staging system and because the prevalence of the disease as defined by the staging system has risen from 10% (in 1988-94) to 13% (in 1999-2004) of the non-institutionalised adult US population.5 6 7 The staging system (which comprises five stages, 1-5) defines chronic kidney disease on the basis of either evidence of kidney damage (proteinuria, haematuria, or anatomical abnormality) or an impaired glomerular filtration rate <60 ml/min/1.73 m2, present on at least two occasions over three months or longer. The use of a threshold
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