Published 16 September 2008, doi:10.1136/bmj.a1668
Cite this as: BMJ 2008;337:a1668

Letters

Hormone replacement therapy

HRT in premature menopause

The first 100% of the full text of this article appears below.

Grant’s blanket statement,1 based on the WISDOM study,2 that "it would be irresponsible to think that any use of hormone replacement therapy (HRT) is justifiable" will confuse those dealing with women with early ovarian failure in their 20s and 30s. National guidelines recommend the use of HRT in this group until the average age of the natural menopause in the early 50s.3 The results of the WISDOM study, which randomised women with a mean age of 63.8 years, should not be extrapolated to them.

Cite this as: BMJ 2008;337:a1668

Margaret C P Rees, reader in reproductive medicine, University of Oxford1

1 Women’s Centre, John Radcliffe Hospital, Oxford OX3 9DU

margaret.rees@obs-gyn.ox.ac.uk

Competing interests: None declared.

  1. Grant ECG. Hormone replacement therapy: Irresponsible to modify current guidelines BMJ 2008;337:a1494. (3 September.)[Free Full Text]
  2. Welton AJ, Vickers MR, Kim J, Ford D, Lawton BA, MacLennan AH, et al, for the WISDOM team. Health related quality of life after combined hormone replacement therapy: randomised controlled trial. BMJ 2008;337:a1190. (21 August.)[Abstract/Free Full Text]
  3. British Menopause Society. BMS consensus statements: summary and practice points. Premature menopause. www.thebms.org.uk/statementpreview.php?id=3

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