Published 8 September 2008, doi:10.1136/bmj.a1397
Cite this as: BMJ 2008;337:a1397

Clinical Review

Management of sickle cell disease

¹ Service de Pédiatrie Générale, Hôpital Necker, 75015 Paris

The first 150 words of the full text of this article appear below.

Care for patients with sickle cell disease requires a network of doctors Patients with sickle cell disease should receive annual follow-up investigations, such as blood counts, hepatic and renal tests, transcranial Doppler ultrasonography for children, heart and liver ultrasonography Immunisation is needed for pneumococcus, Haemophilus influenzae type B, meningococcus, and influenza virus The most frequent complications are painful crises, acute anaemia, and infections Patients sometimes need admission to intensive care, in particular for treatment of refractory pain and for exchange transfusion Patients and their families need education and support Genetic counselling and prenatal diagnosis may be offered to at-risk couples

About 250 000 children are born with sickle cell disease every year. Although most people with the disease live in Africa, where the sickle mutation appeared several thousand years ago,¹ sickle cell disease has become common in the United States and Europe since the migration of African people. About 60 . . . [Full text of this article]

Management of acute pain in patients with sickle cell disease

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