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Published 6 August 2008, doi:10.1136/bmj.a1131
Cite this as: BMJ 2008;337:a1131
| The first 150 words of the full text of this article appear below. |
There is very good epidemiological evidence that melanoma is related to UV exposure that Shuster has not cited.1 Marks has shown that the public health campaign in Australia has shown not only a decrease in the incidence of melanoma but also an increase in the detection of early, treatable lesions.2 Despite this positive progress, Queensland, a tropical region, has the dubious honour of having the worlds highest incidence of melanoma. Is it Shusters assertion that the white Anglo-Saxon and Celtic majority living in this area somehow have inherited genetically unstable melanocytes? Alternatively, is it his assertion that Queensland has a particularly overzealous and poorly trained group of pathologists?
The role of intermittent, high intensity exposure has been suggested as the mechanism by which UV light induces malignant change in melanocytes.3 Intermittent ionising radiation is a well recognised and well documented model for inducing other cancers, most notably sarcomas.4 Shuster suggests
Marc D Moncrieff, consultant plastic surgeon1, Jennifer Garioch, chairperson and dermatologist2
1 Norfolk and Norwich University Hospital, Norwich. NR4 7UY, 2 Skin Cancer Multidisciplinary Team, Norfolk and Norwich University Hospital Foundation NHS Trust
marc@moncrieff.net