BMJ  2008;336:1298-1302 (7 June), doi:10.1136/bmj.39582.589433.BE

Clinical Review

Diagnosis and management of hypocalcaemia

Mark S Cooper, senior lecturer and consultant endocrinologist, Neil J L Gittoes, senior lecturer and consultant endocrinologist

1 Division of Medical Sciences, University of Birmingham, Birmingham B15 2TH

Correspondence to: N J L Gittoes, Department of Endocrinology, Queen Elizabeth Hospital, Birmingham B15 2TH n.j.gittoes@bham.ac.uk

The first 150 words of the full text of this article appear below.

Hypocalcaemia is a potentially life threatening biochemical abnormality that carries risks for serious errors in diagnosis and treatment. Hypocalcaemia presents in primary and secondary care; it has a prevalence of 18% in all patients in hospital and 85% in the intensive care unit.1 2 The most common cause of hypocalcaemia in primary care is vitamin D deficiency, which—depending on population demographics—may have a prevalence as high as 50%.3 Hypocalcaemia may be an asymptomatic laboratory finding or a life threatening metabolic disturbance. Acute hypocalcaemia can result in severe symptoms that require rapid admission to hospital and correction. In contrast, when hypocalcaemia develops slowly patients can be surprisingly free of symptoms. This review will help clinicians to optimise the diagnosis and management of patients with hypocalcaemia. Because hypocalcaemia often presents as an emergency and symptoms are rapidly reversed by giving calcium, the evidence base for managing acute hypocalcaemia is mostly based on experience . . . [Full text of this article]


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