Prophylaxis against infective endocarditis: summary of NICE guidance

doi:10.1136/bmj.39510.423148.AD

BMJ 2008;336:770-771 (5 April), doi:10.1136/bmj.39510.423148.AD

Practice

Guidelines

Prophylaxis against infective endocarditis: summary of NICE guidance

Roberta Richey, technical analyst¹, David Wray, professor of oral medicine², Tim Stokes, associate director¹, on behalf of the Guideline Development Group

¹ National Institute for Health and Clinical Excellence, Manchester M1 4BD, ² Glasgow Dental School, Glasgow G2 3JZ

Correspondence to: D Wray d.wray@dental.gla.ac.uk

The first 150 words of the full text of this article appear below.

Infective endocarditis is a rare condition with a high mortalityand morbidity. Accepted clinical practice has been to use antibioticprophylaxis in those at risk of infective endocarditis who arehaving dental and certain non-dental interventional procedures,in the belief that this may prevent the development of infectiveendocarditis. The effectiveness of such antibiotic prophylaxisin humans is, however, not proved¹ and recent internationalguidelines recommend a much more limited role for antibioticprophylaxis against infective endocarditis. This article summarisesthe most recent guidance from the National Institute for Healthand Clinical Excellence (NICE) on antibiotic prophylaxis againstinfective endocarditis.²

NICE recommendations are based on systematic reviews of bestavailable evidence. When minimal evidence is available recommendationsare based on the guideline development group’s opinionof what constitutes good practice. With a serious rare condition,such as infective endocarditis, research using experimentalstudy designs is difficult and the evidence base . . . [Full text of this article]

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