BMJ  2008;336:735-736 (5 April), doi:10.1136/bmj.39535.515521.1F

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Helicobacter pylori test and treat versus proton pump inhibitor

Role of H pylori in dyspepsia

The first 150 words of the full text of this article appear below.

The main conclusion to be drawn from the study reported by Delaney et al is that no benefit at 12 month follow-up of dyspeptic patients is to be derived from eradication of Helicobacter pylori combined with a four week course of a proton pump inhibitor compared with a four week course of proton pump inhibitor alone.1

The message to be taken from this is surely that cases of persistent dyspepsia need investigation. Almost certainly, several of these patients would have duodenal ulcers. With this in mind, it would be very interesting to know what the findings were in the group of 99 patients who had eradication treatment for H pylori, and particularly the 57 patients in whom the eradication was confirmed, as almost certainly some of these would have duodenal ulceration and should have benefited from the eradication therapy. This information is not available.

Another message is that this . . . [Full text of this article]

Michael Hobsley, emeritus professor surgery, Frank I Tovey

1 Department of Surgery, University College London, London

m.hobsley@ucl.ac.uk


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Relevant Article

Helicobacter pylori test and treat versus proton pump inhibitor in initial management of dyspepsia in primary care: multicentre randomised controlled trial (MRC-CUBE trial)
Brendan C Delaney, Michelle Qume, Paul Moayyedi, Richard F A Logan, Alexander C Ford, Cathy Elliott, Cliodna McNulty, Sue Wilson, and F D Richard Hobbs
BMJ 2008 336: 651-654. [Abstract] [Full Text] [PDF]

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