BMJ  2008;336:206-210 (26 January), doi:10.1136/bmj.39433.670718.AD

Clinical Review

Benign prostatic hyperplasia. Part 2—Management

Timothy J Wilt, professor of medicine1, James N’Dow, professor of urology2

1 Center for Chronic Disease Outcomes Research, 1 Veterans Drive (111-0), Minneapolis, MN 55417, USA, 2 Academic Urology Unit, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD

Correspondence to: T J Wilt tim.wilt@med.va.gov

The first 150 words of the full text of this article appear below.


Treatment should improve patients’ symptoms and reduce progression and need for surgery while minimising harms and costs
Management includes observation, lifestyle modification, drug treatment, minimally invasive surgery, and surgical removal of prostate tissue
{alpha} blockers are the most effective drug for improving lower urinary tract symptoms and short term quality of life
Combination treatment ({alpha} blockers and 5{alpha}-reductase inhibitors) reduces progression of benign prostatic hyperplasia and need for surgery if the symptoms are moderate or severe and the prostate glands large, if taken for more than a year; adverse events increase
5{alpha}-reductase inhibitors may reduce risk of prostate cancer but may increase the risk of high grade disease
Transurethral resection of the prostate results in the greatest improvement in symptoms and flow rate, but adverse effects include the risk of surgery
Minimally invasive surgery can provide benefits comparable to transurethral resection of the prostate, with fewer serious adverse effects. . . . [Full text of this article]



Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to StumbleUpon StumbleUpon   Add to Technorati Technorati    What's this?

This article has been cited by other articles:

  • Cartwright, N. E K. (2008). {alpha}1 adrenoreceptor antagonists and cataract surgery. BMJ 336: 291-291 [Full text]  

Rapid Responses:

Read all Rapid Responses

α-1 adrenoreceptor antagonists and cataract surgery
Nathaniel E Knox Cartwright
bmj.com, 25 Jan 2008 [Full text]
cranberry juice for prophylaxis against recurrent urinary tract infestion in BPH
oscar,m jolobe
bmj.com, 25 Jan 2008 [Full text]
Combined Pharmacotherapy with 5ARI inhibitors and alpha1 adreno receptors inhibitors is not cost effective than surgical TURP for long term treatment of Benign hyperplasia of Prostate in third world countries.
Professor Pranab Kumar Bhattacharya, et al.
bmj.com, 12 Feb 2008 [Full text]
Access jobs at BMJ Careers
Whats new online at Student BMJ