Cervical intraepithelial neoplasia and higher long term risk of cancer

doi:10.1136/bmj.39364.439444.80

BMJ 2007;335:1053-1054 (24 November), doi:10.1136/bmj.39364.439444.80 (published 24 October 2007)

Editorials

Cervical intraepithelial neoplasia and higher long term risk of cancer

Women treated for CIN3 should have long term regular screening,even if they are beyond the normal age limit

The first 150 words of the full text of this article appear below.

In some countries, such as the United Kingdom, women have longterm intensive surveillance after conservative treatment forhigh grade cervical intraepithelial neoplasia, whereas in others,such as the Netherlands and Finland, they return to regularscreening after a few years. The second choice is based on theconsistent observation that most recurrences of cervical intraepithelialneoplasia occur in the first two to three years after treatment.¹

In this week's BMJ, Strander and colleagues provide strong evidencethat women treated for cervical intraepithelial neoplasia grade3 have a long lasting excess risk of invasive cervical cancer.²Among more than 130 000 women with this condition, the age adjustedincidence was more than double that of the general populationup to 20-25 years after diagnosis. The excess incidence wasgreater in women treated at older age and in recent years.

How do these findings translate into clinical recommendations?The important . . . [Full text of this article]

Guglielmo Ronco, responsible for cervical screening evaluation unit¹, Mario Giovanni Sideri, director², Stefano Ciatto, director³

¹ Unit of Cancer Epidemiology, Centre for Cancer Prevention, 10123 Torino, Italy, ² Preventive Gynaecology Unit, European Institute of Oncology, 20141 Milan, Italy, ³ Department of Diagnostic Imaging, Scientific Institute for Cancer Prevention of Tuscany Region, 50131 Florence, Italy

guglielmo.ronco@cpo.it

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Long term risk of invasive cancer after treatment for cervical intraepithelial neoplasia grade 3: population based cohort study: Björn Strander, Agneta Andersson-Ellström, Ian Milsom, and Pär Sparén
BMJ 2007 335: 1077. [Abstract] [Full Text] [PDF]

Rapid Responses:

Read all Rapid Responses

Routine screening programme: Victoria M. Pickles
bmj.com, 25 Nov 2007 [Full text]
After treatment of CIN, 66% of post-treatment disease is detected more than 2 years after treatment and is 6 times more common if the margins were involved.: William P Soutter, et al.
bmj.com, 27 Nov 2007 [Full text]
Author's reply: Guglielmo Ronco, et al.
bmj.com, 7 Dec 2007 [Full text]