BMJ 2007;335:558-562 (15 September), doi:10.1136/bmj.39316.442338.AD
Clinical Review
Clinical review
Adult coeliac disease
Andrew D Hopper, gastroenterology specialist registrar1,
Marios Hadjivassiliou, consultant neurologist2,
Sohail Butt, general practitioner3,
David S Sanders, consultant gastroenterologist1
1 Department of Gastroenterology, Royal Hallamshire Hospital, Sheffield S10 2JF,
2 Department of Neurology, Royal Hallamshire Hospital,
3 Studholme Medical Centre, Ashford TW15 2TU
Correspondence to: A D Hopper, Room P39, P Floor, Gastroenterology and Liver Unit, Royal Hallamshire Hospital, Sheffield S10 2JF. andydhopper@aol.com
| The first 150 words of the full text of this article appear below. |
- The prevalence of coeliac disease is 0.5-1% in international population studies
- A combination of tissue transglutaminase antibody, endomysial antibody, and immunoglobulin A should be used for initial testing
- Antibody negative coeliac disease with villous atrophy is now recognised
- Treatment should involve a gluten-free diet, with support from a dietitian and a gastroenterologist
| |
The prevalence of coeliac disease is 0.5-1% in international population studies. The delay in diagnosis is reported to range from 4.5 years to 9.0 years.1 2 Patients may present on numerous occasions to both primary and secondary care without coeliac disease being considered.3 Currently, for every adult patient in whom the disease is diagnosed, eight cases are estimated to go undetected.4
Coeliac disease (or gluten sensitive enteropathy) is defined as a state of heightened immunological responsiveness to ingested gluten (from wheat, barley, or rye) in genetically susceptible individuals. Coeliac disease has historically been considered to . . . [Full text of this article]

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