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BMJ 2007;335:44 (7 July), doi:10.1136/bmj.39239.478495.80
Chris M Laing, specialist registrar in nephrology1, Rhys Roberts, senior house officer in medicine2, Liz Lightstone, consultant nephrologist1, Alison Graham, consultant radiologist3, Terry H Cook, professor of renal pathology4, Shaun Summers, specalist registrar in nephrology and internal medicine1, Charles D Pusey, professor of medicine5
1 West London Renal and Transplant Centre, Hammersmith Hospital, London W12 0HS, 2 Department of Medicine, Hammersmith Hospital, London W12 0HS, 3 Department of Radiology, Hammersmith Hospital, 4 Division of Investigative Science, Imperial College London, Hammersmith Hospital Campus, London W12 0NN, 5 Division of Medicine, Imperial College London, Hammersmith Hospital Campus
Correspondence to: Chris M Laing christopher.laing@mac.com
| The first 150 words of the full text of this article appear below. |
Last week (30 June; doi: 10.1136/bmj.39212.564745.BE) we described the case of a 46 year old woman who presented after a possible miscarriage with severe hypertension, acute renal failure, alveolar infiltrates on chest radiography, thrombocytopenia, and grand mal convulsions.
Initially, she was given an intravenous infusion of lorazepam, frusemide, and a nitrate. A computed tomography scan of the brain excluded acute haemorrhage. She was then transferred to the renal unit of the Hammersmith Hospital.
On arrival, she remained severely hypertensive at 200/120 mm Hg. Fundoscopy demonstrated flame haemorrhages and papillo-oedema. She had severe peripheral and pulmonary oedema. Urine microscopy demonstrated red blood cells but no red cell casts. Her haemoglobin continued to fall to 8.4 g/l, with 11% reticulocytes, and her creatinine rose to 709 µmol/l.
We thought that thrombocytopenia, red cell fragmentation on blood film, raised bilirubin concentrations, and raised lactate dehydrogenase concentrations were consistent with a diagnosis of
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