BMJ  2007;334:1372 (30 June), doi:10.1136/bmj.39212.564745.BE

Practice

Interactive case report

A patient with suspected miscarriage is found to have hypertension, renal failure, and thrombocytopenia: case presentation

Chris M Laing, specialist registrar in nephrology1, Rhys Roberts, senior house officer in medicine2, Liz Lightstone, consultant nephrologist3, Alison Graham, consultant radiologist4, Terry H Cook, professor of renal pathology5, Shaun Summers, specalist registrar in nephrology and internal medicine3, Charles D Pusey, professor of medicine6

1 Critical Care and Internal Medicine, Department of Medicine, University College London Hospital, London NW1 2BU, 2 Department of Medicine, Hammersmith Hospital, London W12 0HS, 3 West London Renal and Transplant Centre, Hammersmith Hospital, 4 Department of Radiology, Hammersmith Hospital, 5 Division of Investigative Science, Imperial College London, Hammersmith Hospital Campus, London W12 0NN, 6 Division of Medicine, Imperial College London, Hammersmith Hospital Campus

Correspondence to: Chris M Laing christopher.laing@mac.com

The first 150 words of the full text of this article appear below.

A 46 year old white woman presented to her local casualty department. She had been experiencing vaginal bleeding for 10 days, and the bleeding had become particularly heavy in the past three days. She had also felt generally unwell for around a week with malaise, fatigue, headaches, anorexia, and vomiting.

She and her partner had been trying to conceive. Her last menstrual period had been 10 weeks ago and she had recently tested positive with a urinary (beta human chorionic gonadotrophin) pregnancy testing kit. She had three children from a previous partner. Two of these pregnancies were complicated by hypertension from 36 weeks onwards. She thought that she may have had two miscarriages the previous year, which had not been investigated.

The previous year she had a measured blood pressure of 165/90 mm Hg. She gave a history suggestive of Raynaud's syndrome but had no other symptoms or past medical . . . [Full text of this article]

Questions


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Rapid Responses:

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I'm glad the patient is there.
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Endothelial disorder
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Possible suggestions would be-
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TTP
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Stabilise then investigate
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Antiphospholipid syndrome +/- SLE???
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Delay in starting the plasma exchange = treatment failure
Hawraman Ramadan
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Systematic approach is necessary
Rishu Tandon
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Hypertension is the key
C M Morgan
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Author interjection
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? secondary TTP (related to collagen vascular disease)
Thein H Oo, MD, FRCP
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hellp
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???Scleroderma renal crisis
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TTP/HUS
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