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BMJ 2007;334:1346-1348 (30 June), doi:10.1136/bmj.39240.416968.AD
Alison Tonks, associate editor
BMJ, London WC1H 9JR
atonks@bmj.com
Researchers broadly agree that the best way to halt the AIDS epidemic is to develop a vaccine against HIV. But despite huge investment a vaccine is proving elusive, as Alison Tonks explains
| The first 150 words of the full text of this article appear below. |
The AIDS pandemic is now more than 25 years old, and for most of its history, scientists have been searching for an effective vaccine against HIV. There have been many false dawns, dashed hopes, and disappointments along the way as evangelical rhetoric has eventually given way to a more pragmatic acceptance that a vaccine would be great, and may even be possible, but it won't be on offer at a clinic near you any time soon. The most optimistic experts predict it will be at least another 10 years before any kind of vaccine is available1; the most pessimistic say it could take 50. Even then, the first vaccines will probably be only partially effective.2 Why is such an important task taking so long?
HIV is one of the most complex viruses ever identified, and it's extremely good at evading any immune mediated strategy directed against it. HIV is
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