BMJ  2007;334:1177-1178 (9 June), doi:10.1136/bmj.39233.510810.80 (published 4 June 2007)

Editorials

Clinical trial registration

Looking back and moving ahead

The first 150 words of the full text of this article appear below.

In 2005, the International Committee of Medical Journal Editors (ICMJE) initiated a policy requiring investigators to deposit information about trial design into an accepted clinical trials registry before the onset of patient enrolment.1 This policy aimed to ensure that information about the existence and design of clinically directive trials was publicly available, an ideal that leaders in evidence based medicine have advocated for decades.2 The policy precipitated much angst among research investigators and sponsors, who feared that registration would be burdensome and would stifle competition. Yet, the response to this policy has been overwhelming. The ICMJE promised to re evaluate the policy two years after implementation. Here, we summarise that re-evaluation, specifically commenting on registries that meet the policy requirements, the types of studies that require registration, and the registration of trial results. As is always the case, the ICMJE establishes policy only for the 12 member journals (a detailed . . . [Full text of this article]

Christine Laine, senior deputy editor, Annals of Internal Medicine, Richard Horton, editor, Lancet, Catherine D DeAngelis, editor-in-chief, JAMA, Jeffrey M Drazen, editor-in-chief, New England Journal of Medicine, Frank A Frizelle, editor-in-chief, New Zealand Medical Journal, Fiona Godlee, editor-in-chief, BMJ, Charlotte Haug, editor-in-chief, Norwegian Medical Journal, Paul C Hébert, editor-in-chief, CMAJ, Sheldon Kotzin, executive editor, MEDLINE, National Library of Medicine, Ana Marusic, Editor, Croatian Medical Journal, Peush Sahni, representative and past president, World Association of Medical Editors, Torben V Schroeder, editor, Journal of the Danish Medical Association, Harold C Sox, editor, Annals of Internal Medicine, Martin B Van Der Weyden, editor, Medical Journal of Australia, Freek W A Verheugt, executive editor, Nederlands Tijdschrift voor Geneeskunde (Dutch Journal of Medicine)

claine@mail.acponline.org


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