BMJ  2007;334:1073 (26 May), doi:10.1136/bmj.39224.364630.DB

News

Study indicates diabetes drug linked to cardiovascular death

New York

The first 150 words of the full text of this article appear below.

A meta-analysis of 42 trials of the type 2 diabetes drug rosiglitazone (Avandia) has shown a significantly raised risk of myocardial infarction and an increase in cardiovascular deaths that did not quite reach statistical significance (New England Journal of Medicine 2007 May 21 doi: 10.1056/NEJMoa072761).

The analysis by Steven Nissen and Kathy Wolski, of the Cleveland Clinic, Cleveland, Ohio, included 15 560 patients randomly assigned to regimens that included rosiglitazone, and 12 283 patients assigned to regimens that did not. The mean age of patients was 56 years, and the mean baseline glycated haemoglobin concentration was about 8.2%.

Patients receiving rosiglitazone had an odds ratio for myocardial infarction of 1.43 (95% confidence interval 1.03 to 1.98, P=0.03). The odds ratio for death from cardiovascular causes was 1.64 (0.98 to 2.74, P=0.06).

An editorial (doi: 10.1056/NEJMe078099) criticised the Food and Drug Administration for approving the drug on the . . . [Full text of this article]

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

Relevant Articles

FDA needs more funding, NEJM says, amid questions about antidiabetes drug

Janice Hopkins Tanne
BMJ 2007 335: 322. [Extract] [Full Text] [PDF]

FDA committees say keep rosiglitazone available but increase warnings

Janice Hopkins Tanne
BMJ 2007 335: 223. [Extract] [Full Text] [PDF]

Glycaemic control is a myth

Illtyd R Thomas
BMJ 2007 334: 1236. [Extract] [Full Text] [PDF]

FDA places "black box" warning on antidiabetes drugs

Janice Hopkins Tanne
BMJ 2007 334: 1237. [Extract] [Full Text] [PDF]

Prevention of diabetes

Carl Heneghan, M Thompson, and R Perera
BMJ 2006 333: 764-765. [Extract] [Full Text] [PDF]

This article has been cited by other articles:

• Thomas, I. R (2007). Glycaemic control is a myth. BMJ 334: 1236-1236 [Full text]  

Rapid Responses:

Read all Rapid Responses

Glycaemic control is more myth than fact

Illtyd R Thomas
bmj.com, 30 May 2007 [Full text]

Glitazones: Don't throw the baby out with the bath water.

Tahseen A Chowdhury
bmj.com, 30 May 2007 [Full text]

Rosiglitazone: where do we stand?

Sujoy Ghosh, et al.
bmj.com, 31 May 2007 [Full text]

Online poll

Find out more >>