BMJ  2007;334:440 (3 March), doi:10.1136/bmj.39136.475313.FA

Letters

Randomised trials

Beware the "Texas sharp shooter" in rate ratios of progression

The first 150 words of the full text of this article appear below.

Glasziou et al's method of calculating rate ratios of progression (stable unchanging condition before v change shortly after the intervention) is appealing,1 but we need to be wary of a "Texas sharp shooter" effect. This effect is usually associated in epidemiology with the problem of interpreting apparent clusters of disease in space, where the geographical unit of analysis may have been chosen post hoc so as to maximise the apparent density of cases (the sharp shooter metaphor comes from a joke about a Texan firing bullets into the wall of a barn and then drawing the targets around the bullet holes to show his shooting prowess).

An analogous problem may occur when calculating rate ratios in the manner described in this article, although the sharp shooting is in time, not space. In the mother's kiss, the time period used is 10 s, which gives a rate ratio of progression of . . . [Full text of this article]

Anna C Goodman

London School of Hygiene and Tropical Medicine, London WC1E 7HT

anna.goodman@lshtm.ac.uk


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Relevant Article

When are randomised trials unnecessary? Picking signal from noise
Paul Glasziou, Iain Chalmers, Michael Rawlins, and Peter McCulloch
BMJ 2007 334: 349-351. [Abstract] [Full Text] [PDF]




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