BMJ  2006;333:1102-1106 (25 November), doi:10.1136/bmj.39022.423588.DE

Clinical Review

Clinically localised prostate cancer

Timothy J Wilt, professor of medicine1, Ian M Thompson, professor and chair, department of urology2

1 Minneapolis VA Center for Chronic Disease Outcomes Research, 1 Veterans Drive (111-0), Minneapolis, MN 55417, USA, 2 University of Texas Health Science Center, San Antonio, USA

Correspondence to: T J Wilt Tim.wilt@med.va.gov

The first 150 words of the full text of this article appear below.

Prostate cancer is the most commonly diagnosed cancer in United Kingdom men.w1 In 2002 it was diagnosed in 32 000 men, and more than 10 000 deaths were attributed to it. Its incidence increased with the introduction of the prostate specific antigen (PSA) blood test, and disease specific mortality has declined. This review provides evidence about risk factors, prevention, detection, natural course, and treatment, with a focus on clinically localised disease, to guide primary care doctors.


  • Prostate cancer is a common and potentially serious disease
  • Risk factors include increasing age, family history of prostate cancer, and black race. There are few established prevention strategies
  • Early detection and treatment may prevent future cancer-related illness, extend life, and provide peace of mind
  • However, prostate cancer testing, by digital rectal examination and prostate specific antigen testing, can have false positive and false negative results and detects many cancers that would never cause symptoms.
  • . . . [Full text of this article]



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