BMJ  2006;333 (18 November), doi:10.1136/bmj.39036.470278.3A

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In a new analysis of the saline versus albumin fluid evaluation (SAFE) study, the investigators examined (doi: 10.1136/bmj.38985.398704.7C) clinical outcomes of over 6000 Australian patients in intensive care who had been randomized to receive either saline or albumin for their fluid resuscitation. Whether their initial serum albumin levels were high or low, there was no difference in mortality, length of stay, or other outcome variables between the two groups. In an accompanying editorial (doi: 10.1136/bmj.39029.490081.80), J L Vincent points out that the SAFE study was undertaken to establish not whether albumin was better than saline, but whether it was as safe, which it was. He argues that no one would use albumin for all patients needing fluids and advocates a trial comparing albumin and saline in ICU patients who are at increased risk of complications.

Can increased physical activity reduce weight in preschool children? John Reilly et al . . . [Full text of this article]

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