BMJ  2006;333:448 (26 August), doi:10.1136/bmj.333.7565.448-a

Letter

Preventing postoperative nausea and vomiting

Prevention in context

The first 150 words of the full text of this article appear below.

EDITOR—Metoclopramide is one of the drugs that we reviewed in our recent Cochrane meta-analysis.¹ We also found that metoclopramide was effective. We found that, compared with placebo, the average relative risk for postoperative nausea and vomiting was 0.76 for all doses of metoclopramide, which compares to 0.89, 0.75, and 0.63 for 10 mg, 25 mg, and 50 mg of metoclopramide in the study reported by Wallenborn et al.² We would like to comment on the useful information that Wallenborn's study provides in this context.

Wallenborn et al provided the most information linking antiemetic dose with effect. We found a clear pattern of increasing effect in our review for droperidol, but less convincing patterns for other antiemetics, including metoclopramide.¹ Wallenborn et al did not measure a significant difference between 10 mg of metoclopramide and placebo. From our systematic review, we think that 10 mg of intravenous metoclopramide does have . . . [Full text of this article]

Torbay Hospital, Torquay, Devon TQ2 7AA john.carlisle@nhs.net

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