Osteoarthritis

doi:10.1136/bmj.332.7542.639

BMJ 2006;332:639-642 (18 March), doi:10.1136/bmj.332.7542.639

Clinical review

Osteoarthritis

David J Hunter, assistant professor of medicine¹, David T Felson, professor of medicine and public health¹

¹ Boston University Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, USA

Correspondence to: D J Hunter djhunter@bu.edu

The first 150 words of the full text of this article appear below.

Introduction

Osteoarthritis is the most prevalent form of arthritis, withan associated risk of mobility disability (defined as needinghelp walking or climbing stairs) for those with affected kneesbeing greater than that due to any other medical condition inpeople aged ³ 65.^w1 The societal burden (both in terms of personalsuffering and use of health resources) is expected to increasewith the increasing prevalence of obesity and the ageing ofthe community.

Osteoarthritis is a multifactorial process in which mechanicalfactors have a central role and is characterised by changesin structure and function of the whole joint.¹ There is no cure,and current therapeutic strategies are primarily aimed at reducingpain and improving joint function. We searched Medline for relevantarticles (1966 to January 2006) and the Cochrane library (tofirst quarter of 2006) and consulted experts in rheumatologyto produce a narrative review with an update on management . . . [Full text of this article]

What is osteoarthritis?

Epidemiology of osteoarthritis

Diagnosis and investigation

Clinical investigation

Treatment

Pharmacological approach

Analgesics
Intra-articular steroids
Intra-articular hyaluronan

Surgery

Arthroscopic debridement and lavage
Osteotomy
Joint replacement
Conclusion

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Hit parade
BMJ 2006 332: 1100. [Extract] [Full Text]

Physical treatments have valuable role in osteoarthritis: Jan M Bjordal, Rodrigo Alvaro Brandao Lopes-Martins, Bård Bogen, and Mark Johnson
BMJ 2006 332: 853. [Extract] [Full Text]

What works for osteoarthritis?
BMJ 2006 332: 0. [Full Text]

This article has been cited by other articles:

Hernandez-Molina, G, Neogi, T, Hunter, D J, Niu, J, Guermazi, A, Reichenbach, S, Roemer, F W, McLennan, C E, Felson, D T (2008). The association of bone attrition with knee pain and other MRI features of osteoarthritis. Ann Rheum Dis 67: 43-47 [Abstract] [Full text]
Pulichino, A.-M., Rowland, S., Wu, T., Clark, P., Xu, D., Mathieu, M.-C., Riendeau, D., Audoly, L. P. (2006). Prostacyclin Antagonism Reduces Pain and Inflammation in Rodent Models of Hyperalgesia and Chronic Arthritis. J. Pharmacol. Exp. Ther. 319: 1043-1050 [Abstract] [Full text]
(2006). Hit parade. BMJ 332: 1100-1100 [Full text]
Bjordal, J. M, Lopes-Martins, R. A. B., Bogen, B., Johnson, M. (2006). Physical treatments have valuable role in osteoarthritis.. BMJ 332: 853-853 [Full text]

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