BMJ  2006;332:594-596 (11 March), doi:10.1136/bmj.332.7541.594

Practice

ABC of wound healing

Uncommon causes of ulceration

Girish K Patel, research fellow in wound healing and honorary clinical tutor in dermatology

Cardiff University and Cardiff and Vale NHS Trust.

Joseph E Grey, Keith G Harding

The first 150 words of the full text of this article appear below.

This article describes some of the many rare causes of ulceration. Rare causes that are more common in developing countries—such as leprosy, fungal infections, Buruli ulcer, and ulceration resulting from Kaposi sarcoma—are not covered here.


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  		Causes of ulceration, according to typical clinical presentation

 

Inflammatory disorders can lead to ulceration or impair healing directly or through the effect of medication used to treat the disorder; ulceration is a feature of many connective tissue diseases. For example, ulceration develops in up to 10% of patients with rheumatoid arthritis and is often painful. In addition to the underlying disease, impaired healing can result from anaemia, skin atrophy, dependent oedema, deformity, neuropathy, microvascular disease, local factors, or the toxic effects of drugs used in its treatment. Other associated conditions such as vasculitis or pyoderma gangrenosum may also lead to ulceration.


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 Rheumatoid arthritis on dorsum of foot with exposed tendon, and over medial malleolus; such . . . [Full text of this article]

 

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