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BMJ 2006;332:424 (18 February), doi:10.1136/bmj.332.7538.424
| The first 150 words of the full text of this article appear below. |
EDITORKilby drew attention to the increasing incidence of gastroschisis in the United Kingdom, particularly among babies of young mothers.1 This has also been shown by Donaldson and by Mastroiacovo et al (previous letter).2
In the Spanish collaborative study of congenital malformations (ECEMC), an ongoing case-control study and surveillance system,3-5 we have also observed an apparent increasing trend in the birth prevalence of gastroschisis in Spain among mothers younger than 20 but not among older mothers (table).
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Our results do not reach significance, although the sample sizes are small, so we cannot rule out that the observed increase was by chance. However, termination of pregnancy after detecting fetal anomalies has been legal in Spain since 1985, and data on such terminations cannot be obtained
Eva Bermejo, responsible for epidemiology section
ECEMC (Spanish Collaborative Study of Congenital Malformations), CIAC (Centro de Investigación sobre Anomalías Congénitas), Instituto de Salud Carlos III, Sinesio Delgado 6, 28029 Madrid, Spain eva.bermejo@isciii.es
Jacobo Mendioroz, collaborator, Lourdes Cuevas, collaborator, María-Luisa Martínez-Frías, director
ECEMC (Spanish Collaborative Study of Congenital Malformations), CIAC (Centro de Investigación sobre Anomalías Congénitas), Instituto de Salud Carlos III, Sinesio Delgado 6, 28029 Madrid, Spain