Resistance to HIV drugs in UK may be lower in some areas

doi:10.1136/bmj.332.7534.179-c

BMJ 2006;332:179-180 (21 January), doi:10.1136/bmj.332.7534.179-c

Letter

Resistance to HIV drugs in UK may be lower in some areas

The first 150 words of the full text of this article appear below.

Editor—The UK Group on Transmitted HIV Drug Resistancereports an estimated prevalence of transmitted HIV drug resistanceof 14.2% between 1996 and 2003 which is increasing over time.¹Using the same definition of drug resistance as the UK group,a study of primary HIV infection at St Mary's Hospital, London,showed that the prevalence and annual incidence of transmitteddrug resistance have remained low and stable, at 6% (9/140)between 2000 and 2005. Resistance to nucleoside reverse transcriptaseinhibitors was detected in 1/9, to non-nucleoside reverse transcriptaseinhibitors in 5/9, to protease inhibitors in 1/9, and to morethan one class of drug in 2/9.

The disparity in estimated prevalence of transmitted drug resistanceis interesting and may reflect the differences between the twocohorts. In our cohort, all individuals acquired HIV withinsix months of baseline genotyping and were predominantly whitewith homosexually acquired B clade viruses (125/140, 89%).

. . . [Full text of this article]

Julie M Fox, clinical lecturer

Section of Infectious Diseases, Faculty of Medicine, Imperial College, London W2 1PG julie.fox@imperial.ac.uk

Sarah Fidler, clinical senior lecturer, Jonathan Weber, Jefferriss professor

Section of Infectious Diseases, Faculty of Medicine, Imperial College, London W2 1PG

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