BMJ  2005;331:915-916 (22 October), doi:10.1136/bmj.331.7522.915

Editorial

Cervical cancer, human papillomavirus, and vaccination

Vaccines work, but we need more information before widespread immunisation

The first 150 words of the full text of this article appear below.

At the beginning of October one of the trials of vaccines against human papillomavirus (HPV) infection, the primary risk factor for cervical cancer, announced an encouraging result.¹ Large scale, multi-country, multi-site trials of several HPV vaccines are currently under way. The end points comprise incident and persistent HPV infection (during 2-3 years' follow-up) and associated precancerous cytological and histological lesions (cervical intraepithelial (CIN) neoplasia during 2-3 and 4-5 years' follow-up). The World Health Organization is expecting at least one of these vaccines to be licensed for use in 2006.² How promising are the available trial results? What other questions need answering? And is it time to accelerate preparations for programmes to provide HPV vaccination?

The latest data release concerns a trial of a quadrivalent recombinant vaccine that included HPV types 6, 11, 16, and 18.¹ In all, 12 167 women at 90 centres in 13 countries participated in the . . . [Full text of this article]

HIV and STI Department, Health Protection Agency, Centre for Infections, London NW9 5EQ

(Noel.Gill@hpa.org.uk)
HIV and STI Department, Health Protection Agency, Centre for Infections, London NW9 5EQ

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• Van de Velde, N., Brisson, M., Boily, M.-C. (2007). Modeling Human Papillomavirus Vaccine Effectiveness: Quantifying the Impact of Parameter Uncertainty. Am J Epidemiol 165: 762-775 [Abstract] [Full text]  
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Cervical cancer, human papillomavirus, and vaccination

Adam Finn
bmj.com, 25 Oct 2005 [Full text]