BMJ  2005;331:443-445 (20 August), doi:10.1136/bmj.331.7514.443

Clinical review

ABC of asthma

Prevalence

The first 150 words of the full text of this article appear below.

Genetics

Our understanding of the genetics of asthma has recently advanced considerably. A familial link has been recognised for some time together with an association with allergic rhinitis and allergic eczema. The familial link with atopic disorders is strongest in childhood asthma and with the link to maternal atopy. Earlier investigations were helped by studies of isolated communities—such as in Tristan da Cunha, where the high prevalence of asthma can be traced to three women among the original settlers.

View larger version (20K): [in this window] [in a new window]   Family tree of an atopic family

 

Genetic studies
Early studies of genetic links within families with more than one member with asthma suggested a strong link to certain genetic regions of interest, particularly 5q and llq. Further studies in different populations did not replicate all the early findings, and it became evident that, as in other common conditions, the genetic links were not simple. Several issues have been identified, and there seem to be . . . [Full text of this article]

Future investigations
Early environment

Genetic factors and clinical course

Diagnostic criteria in epidemiological studies

Prevalence figures
Changes in prevalence

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