BMJ  2005;331:337-343 (6 August), doi:10.1136/bmj.331.7512.337

Clinical review

Management of severe malaria in children: proposed guidelines for the United Kingdom

¹ Kenya Medical Research Institute/Wellcome Trust Programme, Centre for Geographic Medicine Research-Coast, PO Box 230, Kilifi, Kenya, ² Department of Paediatrics, St Mary's Hospital, London W2 1NY, ³ Department of Paediatrics, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, ⁴ Brighton and Sussex Medical School, Medical Research Building, University of Sussex, Falmer, Brighton BN1 9PS

The first 150 words of the full text of this article appear below.

Introduction

Malaria is the most important vector borne disease worldwide. Globally it results in an estimated 400 million infections and more than 1 million deaths each year.¹ Although malaria is a rare cause of hospital admission in the United Kingdom, it constitutes a substantial health threat for people travelling in endemic areas. The incidence of imported malaria is rising throughout much of the developed world, largely because of a global increase in long distance travel, immigration, and the resurgence of malaria in many tropical countries.^2-4 Moreover, although Plasmodium vivax was once the most common form of imported malaria, it has since been superseded by P falciparum⁵—the only form of malaria that can be lethal—which now accounts for some 80% of reported cases. Around 15% of episodes of malaria occur in children aged 15 years or younger. Most of those affected are UK residents of African ethnicity who have recently visited . . . [Full text of this article]

Methods

Scope of these guidelines

Clinical malaria

Recognition of severe malaria

Emergency assessment and management

Initial assessment and emergency treatments

Respiratory patterns of severe malaria
Circulation
Treatment
Hypovolaemic shock and coma
Further management
Disability: coma
Treatment
Further management
Management of seizures
Raised intracranial pressure
Treatment

General management

Antimalarial medication
Glucose and electrolytes
Role of exchange transfusion
Further management and prognosis

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• Day, N., Dondorp, A. M. (2007). The Management of Patients with Severe Malaria. Am J Trop Med Hyg 77: 29-35 [Abstract] [Full text]  
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