BMJ  2005;330:600-601 (12 March), doi:10.1136/bmj.330.7491.600-b

Letter

Taking folate in pregnancy and risk of maternal breast cancer

Authors' reply

The first 150 words of the full text of this article appear below.

EDITOR—We believe that we have behaved ethically. We emphasised the preliminary nature of our findings and submitted our paper as a research pointer. We worked with the press offices of our universities, the BMJ, and the Department of Health to promote responsible media coverage. The journalist working for the tabloid referred to by Stirrat did not speak to us.

Although we agree that media reporting of scientific articles might be improved, we do not think that suppression of research findings is justified. Greenland et al have argued empirical observations should be reported so that they can be used to develop and test theoretical understandings of disease aetiology.1 It might be more appropriate to ask whether it is ethical not to conduct long term follow up of large randomised trials that produced immediate effects.

Participants in this trial were sequentially allocated to receive pills of different colours. Neither . . . [Full text of this article]

Deborah Charles, research assistant, Doris Campbell, reader in obstetrics and gynaecology, Marion H Hall, emeritus professor

Dugald Baird Centre For Research on Women's Health, Department of Obstetrics and Gynaecology, Aberdeen Maternity Hospital, Aberdeen AB25 2ZL

Andy R Ness, senior lecturer in epidemiology

Unit of Paediatric and Perinatal Epidemiology, Division of Child Health, Bristol BS8 1TQ Andy.Ness@bristol.ac.uk

George Davey Smith, professor of clinical epidemiology

Department of Social Medicine, University of Bristol, Bristol B58 2PR


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to StumbleUpon StumbleUpon   Add to Technorati Technorati    What's this?

Relevant Articles

Preventing neural tube defects in Europe: population based study
Araceli Busby, Lenore Abramsky, Helen Dolk, Ben Armstrong a Eurocat Folic Acid Working Group
BMJ 2005 330: 574-575. [Extract] [Full Text] [PDF]

International retrospective cohort study of neural tube defects in relation to folic acid recommendations: are the recommendations working?
Lorenzo D Botto, Alessandra Lisi, Elisabeth Robert-Gnansia, J David Erickson, Stein Emil Vollset, Pierpaolo Mastroiacovo, Beverley Botting, Guido Cocchi, Catherine de Vigan, Hermien de Walle, Maria Feijoo, Lorentz M Irgens, Bob McDonnell, Paul Merlob, Annukka Ritvanen, Gioacchino Scarano, Csaba Siffel, Julia Metneki, Claude Stoll, Richard Smithells, and Janine Goujard
BMJ 2005 330: 571. [Abstract] [Full Text] [PDF]

Why transition from alternation to randomisation in clinical trials was made
Iain Chalmers
BMJ 1999 319: 1372. [Extract] [Full Text]

Statistics notes: Treatment allocation in controlled trials: why randomise?
Douglas G Altman and J Martin Bland
BMJ 1999 318: 1209. [Extract] [Full Text] [PDF]

Rapid Responses:

Read all Rapid Responses

Coloured Pills
Tom Greenfield
bmj.com, 11 Mar 2005 [Full text]



Access jobs at BMJ Careers
Whats new online at Student 

BMJ