Raised cardiac troponins

doi:10.1136/bmj.328.7447.1028

BMJ 2004;328:1028-1029 (1 May), doi:10.1136/bmj.328.7447.1028

Editorial

Raised cardiac troponins

Causes extend beyond acute coronary syndromes

The first 150 words of the full text of this article appear below.

Cardiac troponins are regulatory proteins of the thin actinfilaments of the cardiac muscle. Troponin T and troponin I arehighly sensitive and specific markers of myocardial injury.Serial measurement of troponin I or troponin T has become animportant tool for risk stratification of patients presentingwith acute coronary syndromes. The joint committee of the EuropeanSociety of Cardiology, the American College of Cardiology, andthe American Heart Association has recently accepted their measurementin serum as the standard biomarker for the diagnosis of acutemyocardial infarction and for diagnosis and management of acutecoronary syndromes.^1
2 Cardiac troponins, however, are raisedin many patients presenting with conditions other than acutecoronary syndromes (box). To ignore this fact will lead to unjustified,potentially harmful investigations and increases medical costs.In sepsis, for example, cardiac troponins are raised in up to85% of patients in the absence of any acute coronary . . . [Full text of this article]

Peter Ammann, senior physician

(peter.ammann@kssg.ch)

Matthias Pfisterer, professor

Division of Cardiology, Department of Internal Medicine, University Hospital Basel, CH-4031 Basel, Switzerland

Thomas Fehr, research fellow

Transplantation Biology Research Center Massachusetts General Hospital, Boston, Boston, MA 02129, USA (thomas.fehr@verizon.net)

Hans Rickli, senior physician

Division of Cardiology, Department of Internal Medicine, Kantonsspital St Gallen, CH-9000 St Gallen, Switzerland (hans.rickli@kssg.ch)

CiteULike

Complore

Connotea

Del.icio.us Add to Digg

Digg

StumbleUpon Add to Technorati

Technorati What's this?

Relevant Articles

Raised cardiac troponins: Troponins seem to be sensitive but not specific: Matthew L Grove
BMJ 2004 329: 111. [Extract] [Full Text]

Raised cardiac troponins: Troponin is raised in pre-eclampsia: Adam Morton
BMJ 2004 329: 111. [Extract] [Full Text]

This article has been cited by other articles:

Dorenkamp, M., Zabel, M., Sticherling, C. (2007). Role of Coronary Angiography Before Radiofrequency Ablation in Patients Presenting With Paroxysmal Supraventricular Tachycardia. J CARDIOVASC PHARMACOL THER 12: 137-144 [Abstract]
Bhattacharyya, M. R., Perkins-Porras, L., Whitehead, D. L., Steptoe, A. (2007). Psychological and clinical predictors of return to work after acute coronary syndrome. Eur Heart J 28: 160-165 [Abstract] [Full text]
Fisher, A. A., Southcott, E. K., Srikusalanukul, W., Davis, M. W., Hickman, P. E., Potter, J. M., Smith, P. N. (2007). Relationships between Myocardial Injury, All-cause Mortality, Vitamin D, PTH, and Biochemical Bone Turnover Markers in Older Patients with Hip Fractures. Annals of Clinical & Laboratory Science 37: 222-232 [Abstract] [Full text]
Strike, P C, Perkins-Porras, L, Whitehead, D L, McEwan, J, Steptoe, A (2006). Triggering of acute coronary syndromes by physical exertion and anger: clinical and sociodemographic characteristics. Heart 92: 1035-1040 [Abstract] [Full text]
Maeder, M., Fehr, T., Rickli, H., Ammann, P. (2006). Sepsis-Associated Myocardial Dysfunction: Diagnostic and Prognostic Impact of Cardiac Troponins and Natriuretic Peptides. Chest 129: 1349-1366 [Abstract] [Full text]
Strike, P. C., Magid, K., Whitehead, D. L., Brydon, L., Bhattacharyya, M. R., Steptoe, A. (2006). Pathophysiological processes underlying emotional triggering of acute cardiac events.. Proc. Natl. Acad. Sci. USA 103: 4322-4327 [Abstract] [Full text]
Hamilton, J S, Sharpe, P C (2005). Two cases of inflammatory muscle disease presenting with raised serum concentrations of troponin T. J. Clin. Pathol. 58: 1323-1324 [Abstract] [Full text]
Vallance, P. (2005). A post-take ward round. JRSM 98: 191-192 [Full text]
Grove, M. L (2004). Raised cardiac troponins: Troponins seem to be sensitive but not specific. BMJ 329: 111-111 [Full text]
Morton, A. (2004). Raised cardiac troponins: Troponin is raised in pre-eclampsia. BMJ 329: 111-111 [Full text]

Rapid Responses:

Read all Rapid Responses

Elevated troponin in pre-eclampsia: Adam P Morton
bmj.com, 5 May 2004 [Full text]
Sensitive but not specific?: Matthew L Grove
bmj.com, 6 May 2004 [Full text]
Heterophile Antibodies: A cause for Raised Cardiac Troponins: Rosemary A Swallow, et al.
bmj.com, 6 May 2004 [Full text]
Reversible or irreversible that is the question. Is it really the question?: Arnold Koller
bmj.com, 7 May 2004 [Full text]
Cardiac Troponins - keeping it simple: Turab Ali
bmj.com, 13 May 2004 [Full text]
Troponin T predicts mortality for asymptomatic hemodialysis patients: Dale M. Needham, et al.
bmj.com, 13 May 2004 [Full text]
Torponin I Rises in Burns: Darryl B Dunn, et al.
bmj.com, 20 May 2004 [Full text]
Additional Causes of Elevated Troponins: Creed L. Wait, M.D.
bmj.com, 16 Jun 2004 [Full text]
matching coronary blood flow to myocardial metabolic needs: Pierre M�gevand
bmj.com, 9 Jul 2004 [Full text]