Danish group reanalyses miscarriage in NSAID users

doi:10.1136/bmj.328.7431.109

BMJ 2004;328:109 (10 January), doi:10.1136/bmj.328.7431.109

Letter

Danish group reanalyses miscarriage in NSAID users

The first 150 words of the full text of this article appear below.

EDITOR—Li et al reported that use of non-steroidal anti-inflammatorydrugs (NSAIDs) in the first half of pregnancy is associatedwith an 80% increased risk of miscarriage, which is in accordancewith our previous results.^1
2

We have since accessed a recent update of our dataset covering1998-2002, including gestational age, which was not originallyaccessible.

We obtained data on miscarriage, and birth and drug exposurewere obtained from a hospital discharge registry and a prescriptiondatabase).² We identified 1599 women with first recorded miscarriage,of whom 45 had filled prescriptions for NSAIDs in the last 12weeks before the miscarriage. As controls we used 10 primigravidasdelivering after the 28th gestational week in the correspondinggestational period (n = 15 990).

Cases and controls were classified as drug exposed if they hadredeemed NSAID prescriptions at appropriate gestational periods.We assessed the association between miscarriage and NSAID usein . . . [Full text of this article]

Gunnar Lauge Nielsen, consultant

uxgln@aas.nja.dk

Mette Vinther Skriver, biostatistician, Lars Pedersen, chief statistician, Henrik Toft Sørensen, professor

Department of Clinical Epidemiology, Aalborg and Aarhus University Hospitals, DK-9000 Aalborg, Denmark

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