BMJ  2003;326 (28 June), doi:10.1136/bmj.326.7404.0-f

Editor's choice

The most important BMJ for 50 years?

The first 150 words of the full text of this article appear below.

I suggest, gentle (or even angry) reader, that you keep this issue of the BMJ. It may well become a collector's item. It's perhaps more than 50 years since we published something as important as the cluster of papers from Nick Wald, Malcolm Law, and others (p 1419, p 1423, and p 1427).

They argue convincingly that a pill with six ingredients could prevent 80% of heart attacks (or other events caused by ischaemic heart disease) and strokes. Anybody with cardiovascular disease would take the pill, and so would everybody from 55—without any investigation. As heart attack, stroke, and other cardiovascular events kill or disable half the population of Britain—and a similar proportion in other developed countries—widespread use of the pill would, write the authors modestly, "have a greater impact on the prevention of disease in the Western world than any other single intervention."

There . . . [Full text of this article]

Richard Smith, editor


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Relevant Articles

Value of low dose combination treatment with blood pressure lowering drugs: analysis of 354 randomised trials
M R Law, N J Wald, J K Morris, and R E Jordan
BMJ 2003 326: 1427. [Abstract] [Full Text] [PDF]

Quantifying effect of statins on low density lipoprotein cholesterol, ischaemic heart disease, and stroke: systematic review and meta-analysis
M R Law, N J Wald, and A R Rudnicka
BMJ 2003 326: 1423. [Abstract] [Full Text] [PDF]

A strategy to reduce cardiovascular disease by more than 80%
N J Wald and M R Law
BMJ 2003 326: 1419. [Abstract] [Full Text] [PDF]

Comparison of methods to identify individuals at increased risk of coronary disease from the general population
S Wilson, A Johnston, J Robson, N Poulter, D Collier, G Feder, and M J Caulfield
BMJ 2003 326: 1436. [Abstract] [Full Text] [PDF]

A cure for cardiovascular disease?
Anthony Rodgers
BMJ 2003 326: 1407-1408. [Extract] [Full Text] [PDF]

Rapid Responses:

Read all Rapid Responses

Beta blockers?
Joseph H. Bolotin, et al.
bmj.com, 27 Jun 2003 [Full text]
Collectors Item
John P Petrie
bmj.com, 27 Jun 2003 [Full text]
It might be the most important for 50 years, but..
Barrie Margetts
bmj.com, 27 Jun 2003 [Full text]
The blue flower and the magic pill
Dr. Herbert Nehrlich
bmj.com, 27 Jun 2003 [Full text]
Old Wine in a New Opaque Bottle!
BM Hegde
bmj.com, 27 Jun 2003 [Full text]
Soma for so many?
Mark Powlson
bmj.com, 27 Jun 2003 [Full text]
Re: Collectors Item
Jeremy G. Jones
bmj.com, 29 Jun 2003 [Full text]
Name that Pill
Chris Manning
bmj.com, 29 Jun 2003 [Full text]
Cardiologists and cardiac surgeons may be better directed elsewhere
James B Woolley, MRCP MRCPsych
bmj.com, 29 Jun 2003 [Full text]
'POLY-PILL' FOR DIABETICS AS WELL?
Henk A Dam van
bmj.com, 29 Jun 2003 [Full text]
Let Them Not Eat Cake!
Robert J Peers
bmj.com, 29 Jun 2003 [Full text]
Polypill is only an hypothesis
Wil A Hoefnagels
bmj.com, 30 Jun 2003 [Full text]
A Birthday present
Felipe H Ramos
bmj.com, 30 Jun 2003 [Full text]
? mega-polypill.
dr.manan vasenwalamd, mrcp
bmj.com, 30 Jun 2003 [Full text]
Reality check: medical cardio prevention [MRFIT, Finnish Executives Study]
Eddie Vos
bmj.com, 30 Jun 2003 [Full text]
Oh Please!!!
Justin Reid
bmj.com, 2 Jul 2003 [Full text]
Healthy Rapid Response e-Forum
Eric Beeth
bmj.com, 7 Jul 2003 [Full text]
Why
B.C. Rao
bmj.com, 15 Aug 2003 [Full text]



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