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Effective in exacerbations with hypercapnic respiratory failure
| The first 150 words of the full text of this article appear below. |
Chronic obstructive pulmonary disease is a
leading cause of global morbidity and mortality, and about 15% of
adults in industrialised countries have chronic obstructive pulmonary
disease when defined by spirometry. Mild exacerbations are common, and
the development of hospital at home services for acute exacerbations
has improved the treatment options for managing mild exacerbations
safely in the community. Severe exacerbations, however, remain the
largest single cause of emergency admissions for respiratory disease
(far higher than for asthma), with a mean hospital stay of around 10 days. According to hospital episode statistics from the Department of
Health, exacerbations of chronic obstructive pulmonary disease resulted
in 135 000 admissions and just under a million bed days in England in
2000-1 (www.doh.gov.uk/hes). These account for over a third of the
overall healthcare costs associated with treating chronic obstructive
pulmonary disease in the United Kingdom. Exacerbations are not only
expensive but can impair lung
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