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EDITOR
In the ABC of psychological medicine Peveler et al discuss
depression in medical patients.1 As a haematologist I often have to respond to depressive reactions in patients with malignant disease who are confronted with a poor prognosis and difficult decisions about treatment. Some degree of this reactive demoralisation is normal and has to be acknowledged. It is
psychological in nature and different from major depression as a
disease of the brain.2 Sometimes the problem is
distinguishing depressed patients with tumours from patients who are
depressed because of tumours.
Most of the studies included in the meta-analysis of drug treatment
taken from the Cochrane review by Gill and Hatcher had to struggle with
this distinction.3 This analysis did not compare tricyclic
antidepressants with selective serotonin reuptake inhibitors, as stated
in the caption of the table; rather it compared drug treatment
(tricyclic antidepressants, tetracyclic antidepressants, and selective
serotonin reuptake inhibitors)